Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R)

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

Masayasu Kojima, Hiroshi Hosoda, Yukari Date et al. · Nature · 1999 · 8.5K citations

Life Sciences, Biochemistry, Endocrinology +10

The Tissue Distribution of the mRNA of Ghrelin and Subtypes of Its Receptor, GHS-R, in Humans

Sharmilee Gnanapavan, Blerina Kola, Stephen A. Bustin et al. · The Journal of Clinical Endocrinology & Metabolism · 2002 · 1.4K citations

Life Sciences, Endocrinology, Physiology +15

Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT

Gianluca Baldanzi, Nicoletta Filigheddu, Santina Cutrupi et al. · The Journal of Cell Biology · 2002 · 729 citations · Full text

Life Sciences, Endocrinology, Pharmacology +16

Structure−Function Studies on the New Growth Hormone-Releasing Peptide, Ghrelin:  Minimal Sequence of Ghrelin Necessary for Activation of Growth Hormone Secretagogue Receptor 1a

Maria A. Bednarek, Scott D. Feighner, Sheng‐Shung Pong et al. · Journal of Medicinal Chemistry · 2000 · 551 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Ghrelin and Des-Octanoyl Ghrelin Promote Adipogenesis Directly in Vivo by a Mechanism Independent of the Type 1a Growth Hormone Secretagogue Receptor

Nichola M. Thompson, Dave A. S. Gill, Rhos Davies et al. · Endocrinology · 2003 · 417 citations · Full text

Life Sciences, Endocrinology, Physiology +17