Cyclooxygenase-2 Overexpression Enhances Lymphatic Invasion and Metastasis in Human Gastric Carcinoma

Abstract

COX-2 overexpression might enhance lymphatic invasion and metastasis in patients with gastric carcinoma, implicating a poor prognosis. Therefore, the use of COX-2-specific inhibitor to suppress lymphatic metastasis in humans should be investigated.