Diagnostic value of single‐photon–emission computed tomography in severe central nervous system involvement of systemic lupus erythematosus: A case‐control study

Abstract

Moderate to severe perfusion defect in SPECT involving multiple regions, especially in the frontal and parietal lobes and basal ganglia, in patients with lupus suggests CNS involvement. SPECT is more sensitive than MRI in revealing damage in diffuse CNS-SLE, and is useful in followup, especially for monitoring disease severity and guiding treatment.