THE CHEMISTRY OF 1,1′-THIOBIS-(2-CHLOROETHANE) (SULPHUR MUSTARD) PART I. SOME SIMPLE DERIVATIVES

Abstract

Abstract Some derivatives of 1,1′-thiobis(2-chloroethane) (sulphur mustard) have been synthesised for use as reference compounds in a wide range of studies embracing analysis, metabolism, environmental degradation and decontamination. Compounds include products formed by hydrolysis, substitution and elimination reactions and their oxidised sulphoxide and sulphone analogues. A comprehensive series of methylthio, methylsulphinyl and methylsulphonyl derivatives has been synthesised in support of metabolic studies.