DentistryOncologyOral PathologyOral DiagnosisOral HistopathologyOral OncologyBenign Oral TumorsBiopsy Of Oral LesionsOral Cancer MetastasisOral Cancer PathologyOral Cavity CancerOral NeoplasiaBenign Oral LesionsEarly DiagnosisHealth Professional ConsultationOral Lesion DetectionSurvival Rates
Oral cancer affects about 30,000 Americans annually, with a 50 % survival rate that can rise to 80 % when detected early, yet early lesions often resemble benign changes, leading to delayed diagnosis and higher risk of local spread and metastasis. Toluidine blue vital staining combined with exfoliative cytology accelerates biopsy of ambiguous lesions, facilitating earlier detection.
Oral cancer currently strikes about 30,000 Americans each year. Survival rates are approximately 50%. However, early detection followed by appropriate treatment can increase cure rates to about 80%, and greatly improves the quality of life by minimizing extensive, debilitating treatments. An early oral cancer can appear as an innocuous red or white change, an ulcer, or a lump, mimicking many benign lesions. Additionally, when the discomfort is minimal, professional consultation often is delayed, increasing the chance for local spread and regional metastases. Vital staining with toluidine blue and exfoliative cytologic examination can aid early detection by accelerating the biopsy of lesions that cannot be classified adequately or made to disappear.
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Proliferative verrucous leukoplakia
Louis S. Hansen, Sol Silverman · Oral Surgery Oral Medicine Oral Pathology · 1985 · 385 citations
J. J. Pindborg, Grete Renstrup, B Roed-Petersen · The Journal of the American Dental Association · 1968 · 246 citations