Catalytic Enantioselective Cross‐Mannich Reaction of Aldehydes

Abstract

A wide variety of optically active compounds as well as active compounds such as amino acid derivatives can be accessed by the cross-Mannich reaction of aldehydes, particularly by the direct catalytic asymmetric version, in which CC bonds are formed. Remarkable advancements have been reported, including one-pot, three-component procedures with absolute stereocontrol and high yields (see example, NMP=N-methylpyrrolidine).