Inhibition of G Protein‐Coupled Receptor 81 (<scp>GPR</scp>81) Protects Against Ischemic Brain Injury

Abstract

G protein-coupled receptor 81 (GPR81) inhibition attenuated ischemic neuronal death. Lactate may aggravate ischemic brain injury by activating GPR81. GPR81 antagonism might be a novel therapeutic strategy for the treatment of cerebral ischemia.