A Randomized Prospective Trial of Airway Pressure Release Ventilation and Low Tidal Volume Ventilation in Adult Trauma Patients With Acute Respiratory Failure

Abstract

For patients sustaining significant trauma requiring mechanical ventilation for greater than 72 hours, APRV seems to have a similar safety profile as the LOVT. Trends for APRV patients to have increased ventilator days, ICU LOS, and ventilator-associated pneumonia may be explained by initial worse physiologic derangement demonstrated by higher Acute Physiology and Chronic Health Evaluation II scores.