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Inhibition of Hepatic Glutathione S-Transferases by a Major Endogenous Ligand Substance Present in Uremic Serum
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1988
Year
Endogenous Ligand SubstancesUremic SerumMedicinal ChemistryPharmacological StudyBioanalysisHepatotoxicityClinical ChemistryHealth SciencesBiochemistryLiver PhysiologyPharmacologyDrug BindingDrug-induced Liver InjuryHepatologyPhysiologyHepatic Glutathione S-transferasesLiver DiseaseMetabolismMedicineDrug Discovery
A major endogenous ligand substance present in uremic serum, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid, inhibited the in vitro activity of bovine and rat liver glutathione S-transferases. Our results suggested that endogenous ligand substances retained in uremic serum have some toxic activities other than the inhibition of drug binding to serum protein observed in uremia.