Statherin SV2 and its analogue. Synthesis and evaluation of antimicrobial activity

Abstract

Statherins are natural peptides derived from human saliva. They may take part in transport of calcium and phosphate and most probably are partly responsible for protection and recalcification of tooth enamel. The solid phase synthesis of statherin SV2 and its dephosphorylated analogue, their purification by solid phase extraction (SPE), as well as the evaluation of their antibacterial activity are presented.