Insulin resistance: a phosphorylation-based uncoupling of insulin signaling

The hormone resistin links obesity to diabetes

Claire M. Steppan, Shannon T. Bailey, Savitha Bhat et al. · Nature · 2001 · 4.8K citations

Life Sciences, Biochemistry, Endocrinology +12

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

Gökhan S. Hotamışlıgil, Pascal Peraldi, Adriane I. Budavari et al. · Science · 1996 · 2.6K citations

Life Sciences, Endocrinology, Molecular Biology +17

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of <i>Ikkβ</i>

Minsheng Yuan, Nicky Konstantopoulos, Jongsoon Lee et al. · Science · 2001 · 1.9K citations

Life Sciences, Endocrinology, Molecular Biology +17

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

Min-Jean Yin, Yumi Yamamoto, Richard B. Gaynor · Nature · 1998 · 1.6K citations

Life Sciences, Immunology, Pharmacology +14

The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307

Vincent Aguirre, Tohru Uchida, Lynne Yenush et al. · Journal of Biological Chemistry · 2000 · 1.5K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15