Molecularly imprinted polymers (MIP) based electrochemical sensor for detection of urea and creatinine

Abstract

In this work, sensors based on molecularly imprinted polymers (MIP) for creatinine and urea selective determination using solvent evaporation processing of poly(ethylene-co-vinyl alcohol), (EVAL) to form molecularly imprinted polymers (MIP) were fabricated. The chemical behaviour of the thin film (MIP) were characterized using FTIR spectrophotometry. The carbonyl functions assigned on the spectra confirmed capture and removal (after rinsing with 20 mL of ethanol) of template molecule. Electrochemical impedance method was employed as transduction technique. The EIS (Electrochemical Impedance Spectroscopy) sensor response shows a limit of detection of 10 ng/mL with linear range from 0.02 μg/mL to 3 μg/mL for urea and 40 ng/mL of detection limit with linear range from 0.05 μg/mL to 2 μg/mL for creatinine with a good specificity of detection.