Seizure, Neuron Loss, and Mossy Fiber Sprouting in Herpes Simplex Virus Type 1–Infected Organotypic Hippocampal Cultures

Abstract

These results suggest that a direct change in the excitability of the hippocampal CA3 neuronal network and HSV-1-induced neuron loss resulting in subsequent mossy fiber reorganization may play an important role in the generation of epileptiform activity.