Infusion of a monoamine oxidase inhibitor into the locus coeruleus can prevent stress-induced behavioral depression

Experimental Design: Procedures for the Behavioral Sciences.

Sidney Addelman, Roger E. Kirk · Journal of the American Statistical Association · 1969 · 5.2K citations

Public Health, Behavioral Sciences, Psychology +14

Depression: a new animal model sensitive to antidepressant treatments

Roger D. Porsolt, Manuel Pichon, M Jalfre · Nature · 1977 · 4.4K citations

Medicine, Neuroscience, Psychiatry +12

Failure to escape traumatic shock.

Martin E. P. Seligman, Steven F. Maier · Journal of Experimental Psychology · 1967 · 1.9K citations

Social Sciences, Psychology, Biological Psychology +8

Effects of inescapable shock upon subsequent escape and avoidance responding.

J. Bruce Overmier, Martin E. P. Seligman · Journal of Comparative and Physiological Psychology · 1967 · 1.2K citations

Public Health, Psychology, Behavioral Neuroscience +9

Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine

T.H. Svensson, B.S. Bunney, George K. Aghajanian · Brain Research · 1975 · 1K citations

Life Sciences, Neuroscience, Pharmacology +14