Asymmetric synthesis of α‐aminophosphonic acids, I enantioselective synthesis of L‐(1‐aminoethyl)phosphonic acid by asymmetric catalytic hydrogenation of <i>N</i>‐[1‐(dimethoxyphosphoryl)ethenyl]formamide

Abstract

Abstract The synthesis of N ‐[bis(dimethoxyphosphoryl)methyl]formamide ( 7 ) from aminomethylene‐bis(phosphonic acid) ( 6 ) is described. 7 reacts with aldehydes in a Wittig‐Horner reaction to give N ‐[1‐(dimethoxyphosphoryl)‐1‐alkenyl]formamides 3 . From the parent compound 3a L‐(1‐amino‐ethyl)phosphonic acid ( 1 ) is obtained with e.e. ca. 76% via asymmetric catalytic hydrogenation using a rhodium catalyst in the presence of (+)‐DIOP.