SYNTHESIS OF SOME SECONDARY AMINE DERIVATIVES BEARING A HETEROARYL FRAGMENT

Abstract

Diverse N-(heteroarylmethyl)anilines were easily prepared from corresponding aldimines derived from commercially available aromatic aldehydes and anilines. New series of substituted NH-tetrahydroquinolines were also prepared using imino-Diels-Alder reaction between aldimines and N-vinylpyrrolidin-2-one in the presence of BF3.OEt2 and the multi-component condensation reactions using a friendly ecological catalyst (BiCl3). The secondary amines obtained bearing a heteroaryl moiety were tested as possible antibacterial and antifungal agents