The hand‐foot‐genital syndrome: on the variable expression in affected males

Abstract

Fryns JP, Vogels A, Decock P, Van den Berghe H. The hand‐foot‐genital syndrome: on the variable expression in affected males. Clin Genet 1993: 43: 232–234. © Munksgaard, 1993 In this report we document male‐to‐male transmission in the hand‐foot‐genital syndrome. An affected father transmitted the syndrome to his three sons. A grade IV hypospadias, which was the most severe genital anomaly in affected males, was present in the youngest, moderately mentally retarded microcephalic male sibling.