The Last Step of the Biosynthesis of the Cyanotoxins Cylindrospermopsin and 7‐<i>epi</i>‐Cylindrospermopsin is Catalysed by CyrI, a 2‐Oxoglutarate‐Dependent Iron Oxygenase

Abstract

Unstereoselective by nature: CyrI is a 2-oxoglutarate-dependent iron oxygenase that catalyses the last step of the biosynthesis of the cyanobacterial cytotoxin cylindrospermopsin, by hydroxylating 7-deoxy-cylindrospermopsin. The stereoselectivity of this enzyme varies from strain to strain, which suggests that 7-epi-cylindrospermopsin should be considered a new member of the cyanobacterial toxin family. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.