Major-Histocompatibility-Complex Class I Alleles and Antigens in Hematopoietic-Cell Transplantation

Abstract

HLA class I antigen mismatches that are serologically detectable confer an enhanced risk of graft failure after hematopoietic-cell transplantation. Transplants from donors with a single class I allele mismatch that is not serologically detectable may be used without an increased risk of graft failure.