Duboscic Acid: A Potent α-Glucosidase Inhibitor with an Unprecedented Triterpenoidal Carbon Skeleton from <i>Duboscia macrocarpa</i>

Abstract

Duboscic acid (1), a triterpenoid with a unique carbon backbone, was isolated from Duboscia macrocarpa Bocq. It is the first member of a new class of triterpenoids, for which the name "dubosane" is proposed. Duboscic acid has a potent α-glucosidase inhibition, and its structure was unambiguously deduced by a single-crystal X-ray diffraction study.