Large-Scale Preparation of Iodobenzene Dichloride and Efficient Monochlorination of 4-Aminoacetophenone

Abstract

Large-scale monochlorination of 4-aminoacetophenone using iodobenzene dichloride is described. Special emphasis was given to the characterization of the iodobenzene dichloride and to the development of a practical procedure for handling this agent from the viewpoint of hazards. This process was successfully scaled up in a pilot plant.