Significance of marrow‐derived nicotinamide adenine dinucleotide phosphate oxidase in experimental ischemic stroke

Abstract

This indicates that NOX2, whether present in circulating cells or brain resident cells, contributes to ischemic brain injury and hemorrhage. However, NOX2 from the circulating cells contributed more to the exacerbation of stroke than that from brain resident cells. These data suggest the importance of targeting the peripheral immune system for treatment of stroke.