Journal of Clinical Psychopharmacology · 1992 · 25 citations · 0 references
MedicinePharmacotherapyPsychiatryNeuropsychiatryPsychopharmacologySubstance Use DisordersAddictionDrug DependenceStimulant PharmacologyStimulant PharmacotherapyStimulant TherapyStimulant Use DisordersAcute Stimulant EffectsAdult Stimulant TreatmentAmphetamine TherapyFunctional ImprovementMethylphenidate PharmacologyMethylphenidate TherapyNeurologic DeficitsTherapeutic Use Of Stimulants
Seven patients with AIDS-related cognitive and emotional deficits had neuropsychologic testing and then were treated with methylphenidate or dextroamphetamine in individualized doses. Three patients showed marked functional improvement and 5 of the 7 became more spontaneous, reactive, and animated. Additional neuropsychologic testing showed statistically significant improvement in a subset of tests; however, scores did not return to baseline in tests done after the treatment was discontinued for 1–3 days.