Unprecedented amidation of ‘transient’ aryl thioaldehydes by N,N-dimethylformamide under basic conditions

Abstract

An unprecedented reaction of N,N-dimethylformamide (DMF) with ‘transient’ aryl thiobenzaldehydes, derived from diaryl disulfides under basic conditions, is reported. The unique role of DMF has been generalized to construct a simple method for the synthesis of N,N-dimethyl aryl thioamides. A plausible mechanism for this transformation is discussed.