Metal Complexes of Biologically Important Ligands, LV Binding of Steroidal Hormones through α-Amino Acid Ligands to Platinum(II) and Palladium(II)

Abstract

3-(2-Aminoethoxy)estrone, 3-(2-aminoethoxy)estradiol, 17 α-aminomethylestradiol and 3-ol-17-aminoestrane react with coordinated activated amino acid ligands of platinum(II) and palladium(II) complexes to give cis- and trans-Cl 2 Pt(GlyNHR) 2 , Cl 2 Pt[(Gly)„NHR] 2 and Cl 2 Pd(HisNHR) (R = steroid, n = 1-3). Similarly estrone, prednisolone, prednisone and testosterone have been bound in α-amino acid ester complexes cis-Cl 2 Pt(GlyOR)GlyOH, trans-Cl 2 Pt(GlyOR) 2 and Cl 2 Pd(HisOR) (R = steroid).