The Antiviral Effect of a Triazinoindole (SK&F 40491) in Rhinovirus Infected Gibbons

Abstract

SummarySK&F 40491, a triazinoindole, provided antiviral activity when administered intranasally to gibbons infected with human rhinovirus type 2. The compound was effective in a multidose regimen either as a 0.02% solution or a 2.5% suspension. The effect of drug treatment was demonstrated by a decrease in the quantity of virus recovered from the nose, and by a decrease and delay in serum and nasal antibody response when compared to placebo-treated animals (p < .05).Oral treatment with SK&F 40491 at 16 mg/kg/dose in a multidose regimen did not significantly inhibit viral replication or alter the characteristic antibody response in gibbons infected with rhinovirus 1A when compared to a pooled bank of placebo controls.The authors thank Dr. S. M. Free, Jr., for biostatistical analyses, and Messrs. B. Zabko-Potapovich, P. Ferry, and P. Sereni for excellent technical assistance.