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ROLE OF ACETYLCHOLINE IN CENTRAL VASOMOTOR REGULATION
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References
1967
Year
NeurotransmitterAnesthetic MechanismNeurotransmissionNeuromuscular BlockadeNeurologyNeurochemistryHealth SciencesNeuropharmacologyNervous SystemAnaesthetic AgentFourth VentricleNeurophysiologyNeuroanatomyPhysiologyCentral Vasomotor RegulationPressor ResponseNeuroscienceCentral Nervous SystemAnesthesiaMedicine
The present study was undertaken to investigate the role of acetylcholine in central vasomotor regulation in dogs. Both acetylcholine and carbachol produced a pressor response on intracerebroventricular (i.c.v.) administration. This response was completely blocked by pretreatment with i.c.v. atropine. Administration of hemicholinium into the lateral cerebral ventricle as well as its topical application to the floor of the fourth ventricle depressed the responsiveness of the medullary vasomotor center. Furthermore, choline, a precursor of acetylcholine, reversed the effects of hemicholinium. It is concluded that acetylcholine has an excitatory role in the medullary vasomotor center.