Higher Frontal EEG Synchronization in Young Women with Major Depression: A Marker for Increased Homeostatic Sleep Pressure?

Abstract

Our data imply that young women with MDD live on a higher homeostatic sleep pressure level, as indexed by enhanced FLA during wakefulness. Its positive correlation with depression scores indicates a possible functional relationship. High FLA could reflect a use-dependent phenomenon in depression (enhanced cognitive rumination or tension) and/or an attenuated circadian arousal signal.