Cytology and Genetics · 2009 · 12 citations · 22 references
PharmacyMedicinal ChemistryToxicologyBiochemical ToxicologyDrug DiscoveryStructure-activity RelationshipsChemical Defense In PlantsEnzyme InhibitionMedicinal PlantsMolecular Mechanisms Of ToxicityNatural Product DerivatizationToxic PlantsAntimitotic ActivityAntimitotic DrugsBioactive Plant CompoundsToxicity Of Medicinal PlantsToxicology Of Medicinal Plants
The results of Allium-test screening of new 2,4- and 2,6-dinitroaniline derivates on antimitotic activity and phytotoxicity are presented in the work. It is revealed that all studied compounds which are derivates of 2,4-dinitroaniline, 2,6-dinitro-(4-fluoromethyl)-aniline as well as (methylsulfonyl) nitrobenzol, can evoke a change in mitotic index value, an appearance of cytogenetic damages and also have phytotoxic effect on Allium cepa seedling roots. On data obtained the continuation of investigation the action of N-(2,4-dinitrophenyl)-orto-aminobenzoic acid, N,N-diethyl-2,6-dinitro-4-(trifluoromethyl)-aniline and 1-methylsulfonyl-3-nitrobenzol as potential herbicides is proposed.
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