Malignant Struma Ovarii: A Blinded Study of 86 Cases Assessing Which Histologic Features Correlate With Aggressive Clinical Behavior

Abstract

The clinical outcome of struma ovarii cannot be predicted based on the microscopic diagnosis of the thyroid tissue or on specific histologic features. The lack of correlation between morphology and outcome in proliferative and histologically malignant struma ovarii is striking, making the behavior of these tumors particularly unpredictable.