Effect of Intratesticular Injection of Lindane and Endrin on the Testes of Rats

Abstract

Little is known about the action of different insecticides on the testicular tissue of animals. The administration of lindane and endrin into the rat testis produced hypertrophic and atrophic changes in the testis and induced total arrest of spermatogenesis. Unlike cytotoxic or alkylating agents, the action of these two insecticidal compounds was non‐specific to any group of spermatogenic cells. Intertubular and intratubular regions of the testis showed degenerative changes, necrosis and cellular proliferation. The seminiferous epithelium of the tubules was completely damaged. Formation of multinucleate giant cells of the foreign body type reaction was very common following lindane treatment. The number of spermatozoa and the percentage of deformed (abnormal) spermatozoa was very low after lindane administration as compared to that of endrin.