Journal of Biomedical Materials Research Part B Applied Biomaterials · 2008 · 15 citations · 17 references
PharmacyPharmaceuticsPharmacologyDrug DeliveryPharmacokinetic ModelingPolymer EngineeringControlled Release MechanismsDrug DissolutionDrug DistributionDrug LoadingDrug Release KineticsPolymeric Drug Delivery SystemsContinuum PercolationDrug Diffusion KineticsDrug Diffusion ModelingDrug Loading AnalysisDrug Loading EffectsDrug Release ModelingHydrophobic Matrix SystemsPercolation Transport Models
Abstract A two‐layer dissolution‐diffusion model is derived which incorporates a surface burst component that is estimated from continuum percolation models of overlapping Poisson distributed spheres. The model is shown to adequately describe the release properties of paclitaxel from a hydrophobic polymer matrix, including the surface burst and sustained release dependence on drug loading. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009
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Electrical conductivity in inhomogeneous media
Rolf Landauer · AIP conference proceedings · 1978 · 639 citations