Stereoselective Synthesis of α,α‐Chlorofluoro Carbonyl Compounds Leading to the Construction of Fluorinated Chiral Quaternary Carbon Centers

Abstract

“F-antastic” chiral molecules: Asymmetric syntheses of α,α-chlorofluoro carbonyl compounds have been developed. Nucleophilic substitutions of an α,α-chlorofluoroketone thus obtained with azide or thiol nucleophiles provide various optically active fluorinated compounds without loss of optical purity (see scheme).