Protective Effect of Lafutidine against Indomethacin-Induced Intestinal Ulceration in Rats: Relation to Capsaicin-Sensitive Sensory Neurons

Abstract

These results suggest that lafutidine protects the small intestine against ulceration via stimulation of capsaicin-sensitive sensory neurons. This action may be attributable to inhibition of enterobacterial invasion in the intestinal mucosa, probably by increasing the mucus secretion.