Selective Complexation of N-Alkylpyridinium Salts: Recognition of NAD+ in Water

Abstract

A molecular clip made of two naphthalene side walls and bisphosphonate arms selectively binds to N-alkylpyridinium ions in water. Through the unique potential of this clip to combine π–cation and electrostatic interactions with the hydrophobic effect, the host molecule is able to complex NAD+ (nicotinamide adenine dinucleotide; see picture) efficiently in aqueous solution. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2002/z17918_s.pdf or from the author. NAD=nicotinamide adenine dinucleotide Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.