Acute Humanin Therapy Attenuates Myocardial Ischemia and Reperfusion Injury in Mice

Abstract

These data show that HNG provides cardioprotection in a mouse model of myocardial ischemia and reperfusion potentially through activation of AMPK-endothelial nitric oxide synthase-mediated signaling and regulation of apoptotic factors. HNG may represent a novel agent for the treatment of acute myocardial infarction.