Infertility in carriers of two bisatellited marker chromosomes

Abstract

Gentile M, Susca F, Resta N, Stella A, Cascone A, Guanti G. Infertility in carriers of two bisatellited marker chromosomes. Clin Genet 1993: 44: 71–75. © Munksgaard, 1993 Two unrelated sterile patients, a male and a female, with karyotypes characterized by the presence of two supernumerary bisatellited marker chromosomes, were studied with the aid of fluorescence in situ hybridization (FISH). Using alphoid centromeric specific probes, the markers were identified as an idic (15) (pter‐q 11) and a mar (14). In both cases a single accessory bisatellited marker was present in the karyotype of one of the parents. A possible correlation between the excess of constitutive heterochromatin and meiotic disturbances in the two patients is discussed.