One-Pot Synthesis of Optically Active β-Amino-α-methylene Carbonyl Derivatives From α-Amidosulfones Using Quinine-Based Phase-Transfer Catalysts

Abstract

Optically active β-amino-α-methylene carbonyl derivatives (aza-Morita−Baylis−Hillman adducts) were prepared using a one-pot protocol involving an enantioselective Mannich reaction catalyzed by various quinine-based catalysts, followed by a Horner olefination.