Active-Passive Tetanus Immunization

Abstract

McCOMB and Dwyer1 have recently presented data on the passive-active immunization of nonimmune persons against tetanus with the use of fluid toxoid and human tetanus immune globulin (TIG). This study pointed out that other investigators have recommended alum toxoid rather than fluid toxoid for this procedure,2 3 4 but that such preferences have not been adequately confirmed experimentally in man. One purpose of this paper is to present studies in human subjects that bring significant evidence to bear toward the resolution of the question of alum versus fluid tetanus toxoid in this context. A second purpose was to evaluate anxieties that immunologists . . .