Focal, Periocular Delivery of 2-Deoxy-<scp>d</scp>-Glucose as Adjuvant to Chemotherapy for Treatment of Advanced Retinoblastoma

Abstract

This study demonstrates the efficacy of focal, periocular 2-DG as an adjunct to carboplatin chemotherapy to decrease both intratumoral hypoxia and tumor burden. Hypoxia is increasingly present in advanced disease of LH(BETA)T(AG) retinal tumors. The use of glycolytic inhibitors as a therapeutic strategy has the potential to enhance current retinoblastoma treatments.