Beta‐glucosidase 2 knockout mice with increased glucosylceramide show impaired liver regeneration

Abstract

We conclude that increased glucosylceramide affects cytokine- and growth factor-mediated signalling pathways during liver regeneration. Thus, the repression of IL-6/STAT3 signalling pathway seems to be one of the mechanisms for the delay of liver regeneration in GBA2-deficient mice.