The reduction of SU-4885 by adrenal glands and other tissues and its inhibition by ACTH

Abstract

Rat adrenal glands convert 2-methyl-1,2-bis(3-pyridyl)-1-propanone (SU-4885) in vitro to a product with physical and chemical properties indicating the reduction to 2-methyl-1,2-bis(3-pyridyl)-1-propanol. The same compound is also formed by the reduction of SU-4885 with NaBH 4 . The reduction of SU-4885 also occurs in the presence of frog adrenal, rat kidney, and most actively, rat liver tissue, and depends on the concentration of SU-4885 in the incubation medium. Added deoxycorticosterone, at the concentration used, had no effect, but ACTH inhibited the reduction by both adrenal and liver tissue.