Total Syntheses of Heimiol A, Hopeahainol D, and Constrained Analogues

Abstract

IDSI to the rescue: Use of a carefully designed cascade process empowered by the unique reagent IDSI [(Et2SI)2Cl⋅SbCl6] provided the entire [3.2.2] bicyclic core of both targets 1 and 2 in a single, stereocontrolled operation. Use of strain energies assisted in the completion of the natural products. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.