Iodine Catalyzed One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1<i>H</i>)-ones and Thiones: A Simple and Efficient Procedure for the Biginelli Reaction

Abstract

Iodine efficiently catalyzes the Biginelli reaction. This procedure involves a one-pot three-component cyclocondensation of aldehydes, 1,3-dicarbonyl compounds and urea or thiourea to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones or thiones in high yields.