Role of IGF Binding Protein- 1 in the Dawn Phenomenon and Glycemic Control in Children and Adolescents With IDDM

Abstract

We have demonstrated a statistically significant link between the morning risk in IGFBP-1 and plasma glucose. The free fraction of IGF-1 modulated by acute changes in IGFBP-1 may play a direct role. The dawn phenomenon may occur regardless of pubertal stage or glycemic control in children and adolescents with IDDM.