Concepedia

A general glycomimetic strategy yields non-carbohydrate inhibitors of DC-SIGN

Kathleen C. A. Garber, Kittikhun Wangkanont, Erin E. Carlson, Laura L. Kiessling

Chemical Communications · 2010 · 62 citations · 17 references

DOI

Concepts

Abstract

Shikimic acid can be transformed into monovalent and multivalent glycomimetics that target different members of the C-type lectin class, including DC-SIGN, a dendritic cell lectin that facilitates HIV transmission.

References

17

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Yuan Guo, H. Feinberg, E. Conroy et al. · Nature Structural & Molecular Biology · 2004 · 605 citations

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A Novel Mechanism of Carbohydrate Recognition by the C-type Lectins DC-SIGN and DC-SIGNR

Daniel A. Mitchell, Andrew J. Fadden, Kurt Drickamer · Journal of Biological Chemistry · 2001 · 502 citations · Full text

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Controlled Living Ring‐Opening‐Metathesis Polymerization by a Fast‐Initiating Ruthenium Catalyst

Tae‐Lim Choi, Robert H. Grubbs · Angewandte Chemie International Edition · 2003 · 436 citations

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Control of Multivalent Interactions by Binding Epitope Density

Christopher W. Cairo, Jason E. Gestwicki, Motomu Kanai et al. · Journal of the American Chemical Society · 2002 · 388 citations

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Varying the Size of Multivalent Ligands:  The Dependence of Concanavalin A Binding on Neoglycopolymer Length

Motomu Kanai, Kathleen H. Mortell, Laura L. Kiessling · Journal of the American Chemical Society · 1997 · 297 citations

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