Highly Accelerated Reactions in a Microwave Ovem: Synthesis of Heterocycles

Abstract

Efficient synthesis of a wide variety of heterocycles on 0.1 to 200 g scale MS conducted in organic solvents in a c-rcial microwave w e n in a few minutes at a la, energy level.Erlenmeyer flasks were adequate reaction vessels since neither high pressure nor high t-rature w r e involved.Past mitoring of synthetic reactions was achieved by tlc separation and transfer of tlc spot material directly to a solids probe of a chemical ionization mass spectrmter.llicrowave Wen-induced Reaction mhmcament (IIORE!chemistry is not Q e to themlysis: one reaction was conducted successfully in a reaction vial encased in a block of ice. IKfffCaJLTION C-rcialmicrowave w e n s provide a beam of micr-ves set for efficient heating of water.Such ovens can serve as a convenient source of heat in the laboratory; their c-terised versions are coamrrcially available for the acid digestion of ores and minerals in explosion-proof sealed vessels.Biochemists and organic chemists have conducted