6‐Thioguanine in children with acute lymphoblastic leukaemia: influence of food on parent drug pharmacokinetics and 6‐thioguanine nucleotide concentrations

Abstract

Children with ALL demonstrate significant interindividual variation in 6-TG pharmacokinetics. Although there would appear to be a reduction in parent drug Cmax and AUC with food there was no difference in 6-TGN concentrations after 4 weeks of 6-TG. Taking the drug on an empty stomach may not be necessary.