Response of the septic vasculature to prolonged vasopressor therapy with N (omega-monomethyl-L-arginine) and epinephrine in canines

Abstract

The tested doses showed that nitric oxide production was inhibited by L-NMMA in canine septic shock, but mortality and myocardial depression were unaffected. These results suggest that if L-NMMA has a beneficial effect on survival rates in septic shock, it is small.