Carotenoids and related polyenes. Part 3. First total synthesis of fucoxanthin and halocynthiaxanthin using oxo-metallic catalyst

Abstract

The first total synthesis of optically active fucoxanthin 1 and halocynthiaxanthin 2 had been accomplished via the 8-oxo compound 5, efficiently prepared by rearrangement of the α-acetylenic alcohol 10 using oxo-metallic catalyst and subsequent iodine-catalysed double-bond shift.